| Source | M.W. | CAS No. | |||
|---|---|---|---|---|---|
| Structural Info | |||||
| Formulation | Lyophilized in a solution of acetonitrile and TFA. | ||||
| Reconstitution | Before reconstitution, we recommend a brief spin to drive down any material dislodged from the bottom of the tube. The lyophilized peptide should be reconstituted in 10mM HCl or acetic acid. |
||||
| Stability | The lyophilized protein is stable for at least 1 year if stored at -80 °C. Reconstituted protein is stable for at least 1 month at 4 °C, but should be stored in aliquots at -80 °C for longer term. Avoid repeated freeze and thaw. |
||||
| Purity | Greater than 95% as determined by RP-HPLC analysis | ||||
| Biological Activity | Not determined. | ||||
| Country of Origin | USA | ||||
The Notch pathway is an important pathway in stem cell functions. Jagged-1 is a ligand for Notch receptors. This peptide with a sequence of CDDYYYGFGCNKFCRPR has been shown to mimic the function of full-length Jagged-1, and therefore, can be used as an agonist to activate the Notch pathway.
Ref: Nickoloff et al, Cell Death Different, 2002; Sato T et al, Nature, 2009
Nickoloff et al, Cell Death Different, 2002; Sato T et al, Nature, 2009