|Reconstitution||Before reconstitution, we recommend a brief spin to drive down any material dislodged from the bottom of the tube. The compound is soluble in DMSO.|
|Stability||The powder is stable for at least 1 year if stored at -20 °C. The dissolved compound is stable for at least 1 month at 4 °C, but should be stored in aliquots at -20 °C for longer term. Protect from light.|
|Purity||Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.|
|Biological Activity||Tested active for culturing human iPS cells in serum-free medium on Matrigel coated plates.|
|Country of Origin||USA|
Thiazovivin, N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide, is a selective inhibitor of Rho-associated kinase (ROCK).
It protects human ES cells from death in the absence of ECM by regulating E-cadherin mediated cell-cell interaction. Thiazovivin, in combination with inhibitors of the TGF-beta receptor and the MEK kinases, improves reprogramming efficiency dramatically.
Ref: Lin, T., et al. (2009) A chemical platform for improved induction of human iPSCs. Nature Methods. 6(11):